Mazemondet, Orianne and John, Mathias and Maus, Carsten and Uhrmacher, Adelinde M. and Rolfs, Arndt (2009) Integrating Diverse Reaction Types into Stochastic Models - A Signaling Pathway Case Study in the Imperative π-Calculus. In: Winter Simulation Conference, WSC 2009, December 13-16, Austin, TX, USA. Proceedings,, pp. 932-943.
Full text not available from this repository.Abstract
We present a case study of reusing parameters and reactions of a deterministic model of a biochemical system in order to implement a stochastic one. Our investigations base on a model of the Wnt signaling pathway and aim to study the influence of the cell cycle on the pathway's dynamics. We report on our approaches to solve two major challenges: one is to gather and convert kinetic model parameters, e.g. constants for diffusion and enzymatic reactions. The second challenge is to provide the first implementation of reactions that exhibit Michaelis-Menten kinetics into a π-Calculus based approach by deploying the Imperative π-Calculus.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Projects: | GRK dIEM oSiRiS, DiErMoSiS |
