Requirements for Documenting Electrical Cell Stimulation Experiments for Replicability and Numerical Modeling

Budde, Kai and Zimmermann, Julius and Neuhaus, Elisa and Schröder, Max and Uhrmacher, Adelinde M. and van Rienen, Ursula (2019) Requirements for Documenting Electrical Cell Stimulation Experiments for Replicability and Numerical Modeling. In: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 23-27 July 2019, Berlin, Germany. Proceedings, published by IEEE, pp. 1082-1088.

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Thorough documentation of biological experiments is necessary for their replicability. This becomes even more evident when individual steps of in vitro wet-lab experiments are to be incorporated into computer simulation models. In the highly interdisciplinary field of electrical stimulation of biological cells, not only biological but also physical aspects play a crucial role. Simulations may help to identify parameters that influence cells and thereby reveal new insights into mechanisms of the cell biological system. However, missing or misleading documentation of the electrical stimulation step within wet-lab experiments may lead to discrepancies between reported and simulated electrical quantities. In addition, this threatens the replicability of electrical stimulation experiments. Thus, we argue that a minimal set of information is needed to enable a translation of electrical stimulation experiments of biological cells into computer simulation experiments and to support replicability. This set includes detailed information about the electronic devices and components, their set-up as well as the applied stimulus and shall be integrated into an existing guideline for cell biological experiments. Ideally, the documentation should also contain measured properties of the cellular and experimental environment. Furthermore, a realization of our proposed documentation requirements within electronic lab notebooks may provide a crucial step toward a more seamless integration of wet-lab data into simulations. Based on two exemplary studies, we demonstrate the relevance of our claim.

Item Type: Conference or Workshop Item (Paper)
Additional Information: doi: 10.1109/EMBC.2019.8856863
Projects: LaCE

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